WebFeb 7, 2024 · that CIP2A binds to PP2A B56a and B56c tumor suppressor subunits directly. Both the CIP2A N-terminal region and CIP2A dimerization contribute to maximal B56 binding. We further show that B56 bind-ing determines CIP2A protein stability in human cell lines. Together, these results provide important insights into poorly understood WebFeb 8, 2024 · CIP2A is actively exported from the cell nucleus in interphase but, upon nuclear envelope breakdown at the onset of mitosis, gains access to chromatin where it …
CIP2A Inhibits PP2A in Human Malignancies - Cell
WebDurocher D, et al. The CIP2A-TOPBP1 axis safeguards chromosome stability and is a synthetic lethal target for BRCA-mutated cancer. Nature Cancer. 2: 1357-1371. PMID 35121901 DOI: ... Durocher D, Taylor IA, Sarbassova D, Haire LF, Westcott SL, Jackson SP, Smerdon SJ, Yaffe MB. The molecular basis of FHA domain:phosphopeptide binding … WebBenefit from Durocher International’s reliable service and expertise that has expanded to logistics over the past decades. Our logistics team is dedicated to customer satisfaction, … irish liberation army
CIP2A is a prime synthetic-lethal target for BRCA-mutated …
WebAug 22, 2024 · Conclusion: High expression of CIP2A was a poor indicator of the prognosis of EGJA, and CIP2A may be a new biomarker for the diagnosis and treatment of EGJA. The meta-analysis suggested that CIP2A expression can be a predictive marker of overall survival, disease-specific survival, and time to tumor progression in patients with solid … WebCIP2A inactivates protein phosphatase 2A (PP2A) which down-regulates Akt (Protein Kinase B) phosphorylation and stabilizes c-Myc (c-Myc oncogene product) in cancer … WebDaniel Durocher 53BP1 is a chromatin-binding protein that regulates the repair of DNA double-strand breaks by suppressing the nucleolytic resection of DNA termini1,2. irish liberation theology