Web6 de jan. de 2016 · PKM2 physically interacts with HIF-1α in the nuclei of hypoxic human cancer cells and promotes transactivation of HIF-1α target genes by enhancing the … Web14 de set. de 2024 · Prolyl hydroxylase 3 (PHD3) mRNA expression was up-regulated in both cell lines. It has been shown that PKM2 expression is regulated by HIF-1α and that …
PKM2 and HIF-1α regulation in prostate cancer cell lines
WebAims/introduction: Tubulointerstitial fibrosis is a hallmark of diabetic nephropathy and is associated with an epithelial-to-mesenchymal transition (EMT) program and aberrant … Web18 de mai. de 2016 · Here we show that HIF-1α-PDK1-mediated metabolic changes occur in mild hypoxia, where mitochondrial cytochrome c oxidase activity is unimpaired, … chips and crossword
Pyruvate kinase M2 regulates Hif-1α activity and IL-1β
Web2 de dez. de 2012 · Diagram showing the nuclear function of PKM2. PKM2 dimers in the nucleus bind to Oct 4 and HIF-1α and enhance their transcription activity; EGFR signal activates Src tyrosine kinase, which phosphorylates β-catenin at tyrosine (Y) 333 (P-Y333).PKM2 binds Y333-phosphorylated β-catenin, contributing to β-catenin-mediated … Web14 de set. de 2024 · Activation of HIF-1α occurs due to protein stabilization [] by inhibition of the prolyl hydroxylase family (PHD1-3), which hydroxylates specific prolyl residues in the oxygen-dependent degradation (ODD) domain of HIF-1α to enhance its degradation [15, 16].PHD3 also hydroxylates specific proline residues on PKM2 in mild (1% O2) but not … Web6 de jan. de 2015 · Activation of PKM2 using two well-characterized small molecules, DASA-58 and TEPP-46, inhibited LPS-induced Hif-1α and IL-1β, as well as the expression of a … chips and cod