WebTFEB is a master gene for lysosomal biogenesis. [7] It encodes a transcription factor that coordinates expression of lysosomal hydrolases, membrane proteins and genes involved in autophagy. [7] [8] Upon nutrient depletion and under aberrant lysosomal storage conditions such as in lysosomal storage diseases, TFEB translocates from the cytoplasm ... WebNov 20, 2024 · Furthermore, Blimp-1 directly inhibited the transcriptional activity of NF-κB and the transcription of IL6 gene. Conclusion Blimp-1 represses the production of multiple pro-inflammatory cytokines by directly binding the genomic region and restricting the nuclear translocation and transcriptional activity of NF-κB.
BProm description - MolQuest
WebBacteria generally possess multiple σ factors that, based on structural and functional similarity, divide into two families: σ(70) and σ(N) . Many studies have revealed σ factor competition within the σ(70) family, while the competition between σ(N) WebUniProt website fallback message If you are not seeing anything on this page, it might be for multiple reasons: You might have JavaScript disabled: make sure to ... cliff\\u0027s ag
Transcription Factor - Definition, Function & Quiz
WebWe identified a bHLH transcription factor, Tcf21, that is highly expressed in developing and mature podocytes. Because conventional Tcf21 knockout mice die in the perinatal period with major cardiopulmonary defects, we generated a conditional Tcf21 knockout mouse to explore the role of this transcription factor in podocytes in vivo. Tcf21 was ... WebMay 27, 2024 · This identified the -35 and -10 sequences of a putative rpoD17 site (Figure 5A). This is a class of σ70 promoters with a 17 nt spacer region [60]. Plasmid-borne lacZ fusion constructs to RcGTA orfg2 (Figure 5B) were used to investigate whether this putative promoter sequence was required for RcGTA gene expression. WebApr 6, 2024 · Transcriptional regulation exhibits extensive robustness, but human genetics indicates sensitivity to transcription factor (TF) dosage. Reconciling such observations … cliff\u0027s af