Thiol-mediated uptake

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August undefined, 2024

WebThiol-mediated uptake 1–10 has been developed to explain surprisingly efficient cellular uptake of substrates attached to thiol-reactive groups, most notably disulfides. The key … WebApr 12, 2024 · This Perspective focuses on thiol-mediated uptake, that is, the entry of substrates into cells enabled by oligochalcogenides or mimics, often disulfides, and …

Ring Tension Applied to Thiol-Mediated Cellular Uptake

WebJan 17, 2012 · This Perspective focuses on thiol-mediated uptake, that is, the entry of substrates into cells enabled by oligochalcogenides or mimics, often disulfides, and inhibited by thiol-reactive agents. WebJul 1, 2024 · Abstract and Figures. Thiol‐mediated uptake is emerging as method of choice to penetrate cells. This study focuses on irreversible covalent inhibitors of thiol‐mediated uptake. High‐content ... pamela crumpton corsicana

Thiol-Mediated Uptake JACS Au - ACS Publications

WebMay 3, 2024 · This Perspective focuses on thiol-mediated uptake, that is, the entry of substrates into cells enabled by oligochalcogenides or mimics, often disulfides, and … WebJul 6, 2024 · Thiol-mediated uptake is an intriguing process because it works so well but is so poorly understood. 1 The ability of oligochalcogenides, usually disulfides, to facilitate cell penetration has been observed in many variations. 2-14 The unifying theme is dynamic covalent oligochalcogenide exchange with thiols (and/or disulfides) on the cell surface … WebSep 19, 2024 · The thiol-mediated capping step prevents aggregation of the reduced gold atoms and results in the production of stable organic monolayers on the AuNPs. 45, 46, 69 ... Cellular uptake and internalization pathways of AuNPs (Figure 6) are affected by many factors such as particle size, ... pamela csonka divorced

Cyclic Thiosulfonates for Thiol-Mediated Uptake: …

WebApr 12, 2024 · This Perspective focuses on thiol-mediated uptake, that is, the entry of substrates into cells enabled by oligochalcogenides or mimics, often disulfides, and inhibited by thiol-reactive agents. A ... WebThiol-mediated uptake (TMU) refers to cell penetration of dynamic covalent cascade exchangers (CAXs) that can be inhibited by thiol-reactive agents (Figure 1A). 1, 2 TMU excels in cytosolic delivery in deep tissue, 3 and inhibitors are promising with regard to drug discovery, particularly as antivirals. 4-7 So far, the focus has been almost ... エクセル条件付き書式着色WebMar 21, 2024 · This decoupling of inhibition and induction of thiol-mediated uptake is important because the latter is promising for drug delivery, while the former possibly helps to reveal targets associated with antiviral, antithrombotic and antitumor activity, leading to drug discovery. These results are consistent with the working model of thiol-mediated ... pamela crim

"WebSeed-mediated growth is the most extensively utilized method for producing rod-shaped AuNPs. ... and prisms, have been formed to adjust both the cellular uptake and optical properties of AuNPs . Gold nanoprisms’ strong light scattering ... it is an excellent option for exchanging with thiol groups to further modify them to improve particle ... " - Thiol-mediated uptake

Thiol-mediated uptake

Inhibition of Cell Motility by Cell-Penetrating Dynamic Covalent ...

WebNov 23, 2024 · The thiol-mediated uptake of organic molecules similar to alcohols, where oxygen is replaced by a sulfur atom, is one such entry mechanisms used by the human immunodeficiency virus (HIV), as ... WebJul 6, 2024 · Thiol-mediated uptake is an intriguing process because it works so well but is so poorly understood. 1 The ability of oligochalcogenides, usually disulfides, to facilitate …

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WebIt was thus conceivable that thiol-mediated uptake intrinsically assures cytosolic delivery into deep tissue. Thiol-mediated uptake28–39 operates with transporters that are equipped with thiol-reactive motifs, such as poly- or oli-gochalcogenides,o endisul des,atbestcyclicones(COCs),for dynamic covalent exchange40–49 with cellular thiols ... WebOct 11, 2024 · These results indicate that thiol-mediated uptake operates in neither of the membranes of bacteria. COCs are likely to exchange with thiols on the inner, maybe also on the outer membrane, but do not move on. Concerning mammalian cells, the absence of a COC-mediated uptake into bacteria observed in this study disfavors trivial mechanisms, …

WebThe reason for this is thiol-mediated uptake: dynamic covalent exchange with cellular thiols and disulfides that can be inhibited and activated according to the principles of dynamic … WebOct 6, 2024 · The cytosolic delivery of various substrates in 3D multicellular spheroids by thiol-mediated uptake is reported. This is important because most orthodox systems, including polycationic cell-penetrating peptides, fail to deliver efficiently into deep tissue. The grand principles of supramolecular chemistry, that is the pH dependence of dynamic ...

WebOct 6, 2024 · The cytosolic delivery of various substrates in 3D multicellular spheroids by thiol-mediated uptake is reported. This is important because most orthodox systems, including polycationic cell-penetrating peptides, fail to deliver efficiently into deep tissue. The grand principles of supramolecular chemistry, t WebOct 11, 2024 · To test thiol-mediated uptake in bacteria, five antibiotics have been equipped with up to three different COCs: One diselenolane and two dithiolanes. We found that the …

Webexofacial thiols as disulﬁde (VI), thereby inhibiting thiol-mediated uptake. To launch exchange cascades with disulﬁde COCs, the activation of ring opening by ring tension as in 1,2-dithiolanes has proven powerful.38 There is no evidence for signiﬁcant thiol-mediated uptake with 1,2-dithianes, presumably because

WebA 2015 study demonstrated that the modification of folate can effectively improve the uptake of the prodrug system in FR-overexpressing HeLa cells through FR-mediated endocytosis (Figure 4a). In addition, a GSH-responsive small-molecule prodrug 10 delivery system containing a folate-targeting ligand and the hydrophobic antitumor drug CPT was ... pamela c serpe imagesWebABSTRACT: Thiol-mediated uptake is emerging as a powerful method to penetrate cells. Cyclic oligochalcogenides (COCs) have been identiﬁed as privileged scaﬀolds to enable … エクセル条件付き書式特定の文字含むエクセル条件付き書式特定の文字複数WebThe emerging power of thiol-mediated uptake with strained disulfides called for a move from sulfur to selenium. We report that according to results with fluorescent model substrates, cellular uptake with 1,2-diselenolanes exceeds uptake with 1,2-dithiolanes and epidithiodiketopiperazines with regard to efficiency as well as intracellular localization. pamela culnan richmond hillWebThis proof-of-concept study looked at the feasibility of using a thiol–water proton exchange (i.e., CEST) MRI contrast to detect in vivo hepatic N-acetylcysteine (NAC) uptake. The feasibility of detecting NAC-induced glutathione (GSH) biosynthesis using CEST MRI was also investigated. The detectability of the GSH amide and NAC thiol CEST effect at … pamela cveticaninWebFig. 1 In thiol-mediated uptake, dynamic covalent exchange with thiols on the cell surface precedes entry through diﬀerent mecha-nisms. Inhibition of thiol-mediated uptake by … エクセル条件付き書式画像WebMar 22, 2024 · Abstract and Figures. Thiol-mediated uptake is emerging as a powerful method to penetrate cells. Cyclic oligochalcogenides (COCs) have been identified as privileged scaffolds to enable and inhibit ... pamela cruz md lewisville